| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChief | Jul 7 | SPLAN | 362 | $84.30 | $31K |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChiefDERIV | Jun 12 | MPLAN | 21,000 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChiefDERIV | Jun 12 | MPLAN | 7,951 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChiefDERIV | Jun 12 | MPLAN | 19,895 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChiefDERIV | Jun 12 | MPLAN | 12,000 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChief | Jun 12 | SPLAN | 19,842 | $74.05 | $1.5M |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChief | Jun 12 | SPLAN | 41,004 | $73.09 | $3.0M |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChief | Jun 12 | MPLAN | 19,895 | $56.78 | $1.1M |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChief | Jun 12 | MPLAN | 12,000 | $32.60 | $391K |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChief | Jun 12 | MPLAN | 21,000 | $60.89 | $1.3M |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChief | Jun 12 | MPLAN | 7,951 | $60.89 | $484K |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChiefDERIV | Jan 15 | A | 11,250 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChiefDERIV | Jan 15 | A | 13,650 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChiefDERIV | Jan 15 | M | 11,119 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChief | Jan 16 | S | 4,141 | $75.66 | $313K |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChief | Jan 15 | M | 11,119 | $0.00 | — |
| IONIS PHARMACEUTICALS INC | IONS | Holly B. KordasiewiczChiefDERIV | Jan 2 | A | 9,100 | $0.00 | —? |