LIVE FROM THE DATABASETRANSACTIONS 362,430COMPANIES 5,763LATEST TRADE Oct 16UPDATED Oct 17, 12:31 AM

Reporting ownerCIK 0001595855

Opaleye Management Inc.

131 transactions in 7 companies, from November 7, 2025 to October 12, 2026.

Transactions: 1317 companies
Bought · P: $14.7Mopen market
Sold · S: $22.0Mopen market
Net: −$7.4Mnet selling

By company

Where this insider traded.

Company	Ticker	Trades	Bought	Sold
Alpha Cognition Inc.	ACOG	54	$7.7M	—
Sol-Gel Technologies Ltd.	SLGL	26	$6.8M	—
CODEXIS, INC.	CDXS	15	—	$4.8M
Grace Therapeutics, Inc.	GRCE	12	$257K	—
SANUWAVE Health, Inc.	SNWV	11	—	$2.2M
Eton Pharmaceuticals, Inc.	ETON	7	—	$5.8M
HARROW, INC.	HROW	6	—	$9.2M

All transactions

131 in total, newest filings first.

Company	Ticker	Insider	Date	Code	Shares	Price	Value
Grace Therapeutics, Inc.	GRCE	Opaleye Management Inc.10%	Oct 12	P	7,215	$2.02	$15K
Grace Therapeutics, Inc.	GRCE	Opaleye Management Inc.10%	Oct 9	P	5,340	$2.04	$11K
Grace Therapeutics, Inc.	GRCE	Opaleye Management Inc.10%	Oct 8	P	2,077	$2.02	$4K
Grace Therapeutics, Inc.	GRCE	Opaleye Management Inc.10%	Oct 5	P	1,694	$2.06	$3K
Grace Therapeutics, Inc.	GRCE	Opaleye Management Inc.10%	Oct 2	P	20,000	$2.07	$41K
Grace Therapeutics, Inc.	GRCE	Opaleye Management Inc.10%	Oct 1	P	38,796	$2.04	$79K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Oct 1	P	19,050	$8.69	$166K
Grace Therapeutics, Inc.	GRCE	Opaleye Management Inc.10%	Sep 29	P	7,849	$2.09	$16K
Grace Therapeutics, Inc.	GRCE	Opaleye Management Inc.10%4/A	Sep 23	P	5,318	$2.10	$11K
Grace Therapeutics, Inc.	GRCE	Opaleye Management Inc.10%4/A	Sep 21	P	9,771	$2.10	$21K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Sep 25	P	13,426	$8.47	$114K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Sep 24	P	18,337	$8.57	$157K
Grace Therapeutics, Inc.	GRCE	Opaleye Management Inc.10%	Sep 23	P	5,318	$2.10	$11K
Grace Therapeutics, Inc.	GRCE	Opaleye Management Inc.10%	Sep 21	P	9,771	$2.10	$21K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Sep 16	P	27,141	$8.40	$228K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Sep 16	P	53,029	$8.57	$455K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Sep 15	P	3,375	$8.54	$29K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Sep 14	P	40,373	$8.70	$351K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Sep 2	P	900	$68.95	$62K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Sep 1	P	783	$69.52	$54K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Aug 31	P	217	$69.10	$15K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Aug 31	P	5,000	$68.24	$341K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Aug 28	P	5,000	$68.81	$344K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Aug 28	P	20,113	$68.42	$1.4M
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Aug 28	P	10,000	$71.40	$714K
Grace Therapeutics, Inc.	GRCE	Opaleye Management Inc.10%	Aug 14	P	11,608	$2.09	$24K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Aug 12	P	951	$71.50	$68K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Aug 3	P	50,000	$8.00	$400K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jul 31	P	2,900	$7.92	$23K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jul 24	P	130	$7.90	$1K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jul 23	P	49,849	$7.80	$389K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jul 22	P	10,000	$7.83	$78K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jul 22	P	140,237	$7.83	$1.1M
Eton Pharmaceuticals, Inc.	ETON	Opaleye Management Inc.10%	Jul 14	S	13,315	$37.54	$500K
Eton Pharmaceuticals, Inc.	ETON	Opaleye Management Inc.10%	Jul 14	S	15,000	$37.54	$563K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Jul 14	P	920	$73.43	$68K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Jul 13	P	775	$73.89	$57K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Jul 10	P	229	$73.95	$17K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Jul 8	P	300	$73.69	$22K
Eton Pharmaceuticals, Inc.	ETON	Opaleye Management Inc.10%	Jul 7	S	6,685	$38.37	$257K
Eton Pharmaceuticals, Inc.	ETON	Opaleye Management Inc.10%	Jul 7	S	20,000	$38.37	$767K
Eton Pharmaceuticals, Inc.	ETON	Opaleye Management Inc.10%	Jul 6	S	10,000	$38.00	$380K
Eton Pharmaceuticals, Inc.	ETON	Opaleye Management Inc.10%	Jul 2	S	25,000	$37.39	$935K
Eton Pharmaceuticals, Inc.	ETON	Opaleye Management Inc.10%	Jul 2	S	65,000	$37.39	$2.4M
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Jul 2	P	1,400	$71.97	$101K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Jul 1	P	312	$71.99	$22K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jun 26	P	152,336	$6.40	$975K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jun 25	P	197	$6.50	$1K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jun 15	P	4,550	$5.99	$27K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jun 12	P	273	$5.93	$2K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jun 11	P	2,862	$5.91	$17K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jun 10	P	5,872	$5.99	$35K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jun 9	P	24,856	$5.98	$149K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Jun 5	P	10,054	$5.83	$59K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	May 29	P	70,577	$5.90	$416K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	May 28	P	2,000	$5.83	$12K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	May 27	P	1,161	$5.73	$7K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	May 20	P	1,563	$64.43	$101K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	May 21	P	15,945	$5.70	$91K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	May 20	P	8,431	$5.89	$50K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	May 18	P	17,395	$5.69	$99K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	May 15	P	16,648	$5.83	$97K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	May 13	P	1,937	$66.87	$130K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	May 12	P	1,500	$67.98	$102K
SANUWAVE Health, Inc.	SNWV	Opaleye Management Inc.10%	May 1	S	500	$16.11	$8K
SANUWAVE Health, Inc.	SNWV	Opaleye Management Inc.10%	May 1	S	10,081	$16.11	$162K
SANUWAVE Health, Inc.	SNWV	Opaleye Management Inc.10%	Apr 30	S	1,000	$16.15	$16K
SANUWAVE Health, Inc.	SNWV	Opaleye Management Inc.10%	Apr 30	S	24,000	$16.15	$388K
SANUWAVE Health, Inc.	SNWV	Opaleye Management Inc.10%	Apr 29	S	1,000	$17.25	$17K
SANUWAVE Health, Inc.	SNWV	Opaleye Management Inc.10%	Apr 29	S	23,360	$17.25	$403K
SANUWAVE Health, Inc.	SNWV	Opaleye Management Inc.10%	Apr 28	S	2,500	$18.47	$46K
SANUWAVE Health, Inc.	SNWV	Opaleye Management Inc.10%	Apr 28	S	43,788	$18.47	$809K
SANUWAVE Health, Inc.	SNWV	Opaleye Management Inc.10%	Apr 21	S	202	$20.50	$4K
SANUWAVE Health, Inc.	SNWV	Opaleye Management Inc.10%	Apr 17	S	5,000	$20.46	$102K
SANUWAVE Health, Inc.	SNWV	Opaleye Management Inc.10%	Apr 17	S	11,267	$20.46	$231K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 30	P	1,850	$4.99	$9K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 27	P	10,000	$5.08	$51K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 26	P	7,319	$5.28	$39K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 25	P	8,581	$5.43	$47K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 24	P	4,182	$5.59	$23K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Mar 24	P	5,000	$72.00	$360K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Mar 24	P	34,665	$72.00	$2.5M
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 19	P	2,094	$5.71	$12K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 18	P	2,481	$5.75	$14K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 16	P	1,331	$5.78	$8K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 13	P	7,358	$5.75	$42K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 12	P	5,708	$5.85	$33K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 9	P	2,179	$5.85	$13K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 6	P	1,900	$5.80	$11K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 5	P	5,000	$5.80	$29K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 5	P	42,023	$5.80	$244K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 4	P	19,795	$5.81	$115K
HARROW, INC.	HROW	Opaleye Management Inc.10%	Mar 4	S	4,263	$39.67	$169K
HARROW, INC.	HROW	Opaleye Management Inc.10%	Mar 4	S	134,000	$39.67	$5.3M
HARROW, INC.	HROW	Opaleye Management Inc.10%	Mar 3	S	1,309	$39.15	$51K
HARROW, INC.	HROW	Opaleye Management Inc.10%	Mar 3	S	59,000	$39.15	$2.3M
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 3	P	5,000	$5.75	$29K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 3	P	46,411	$5.75	$267K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Mar 2	P	20,000	$5.80	$116K
HARROW, INC.	HROW	Opaleye Management Inc.10%	Feb 27	S	5,000	$54.18	$271K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Feb 27	P	3,638	$5.99	$22K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Feb 26	P	590	$5.99	$4K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Feb 24	P	5,000	$5.80	$29K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Feb 24	P	53,591	$5.80	$311K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Feb 23	P	4,181	$5.89	$25K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Feb 23	P	95,819	$5.89	$565K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Feb 20	P	2,819	$5.84	$16K
Alpha Cognition Inc.	ACOG	Opaleye Management Inc.10%	Feb 20	P	10,000	$5.84	$58K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Feb 13	P	291	$63.00	$18K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Feb 2	P	100	$58.00	$6K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Jan 27	P	100	$57.05	$6K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Jan 23	P	1,151	$55.98	$64K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Jan 22	P	2,173	$56.57	$123K
HARROW, INC.	HROW	Opaleye Management Inc.10%	Jan 6	S	20,000	$53.35	$1.1M
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Jan 5	P	198	$42.98	$9K
Sol-Gel Technologies Ltd.	SLGL	Opaleye Management Inc.10%	Jan 2	P	2,394	$41.92	$100K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Dec 1	S	8,533	$1.67	$14K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Dec 1	S	245,000	$1.67	$409K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 28	S	2,490	$1.75	$4K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 28	S	105,000	$1.75	$184K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 26	S	5,000	$1.74	$9K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 26	S	148,318	$1.74	$258K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 12	S	165,000	$1.96	$324K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 12	S	27,459	$1.94	$53K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 12	S	890,000	$1.94	$1.7M
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 11	S	13,211	$1.80	$24K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 11	S	535,000	$1.80	$963K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 10	S	3,318	$1.73	$6K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 10	S	205,000	$1.73	$356K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 7	S	10,000	$1.70	$17K
CODEXIS, INC.	CDXS	Opaleye Management Inc.10%	Nov 7	S	296,682	$1.70	$503K