| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDirDERIV | Jul 1 | A | 2,301 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDirDERIV | Jul 1 | A | 5,369 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDirDERIV | May 4 | MPLAN | 16,000 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDirDERIV | May 4 | MPLAN | 12,000 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDirDERIV | May 4 | MPLAN | 16,000 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDirDERIV | May 4 | MPLAN | 10,321 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDirDERIV | May 4 | MPLAN | 12,000 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDirDERIV | May 4 | MPLAN | 10,968 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDir | May 4 | SPLAN | 17,781 | $75.58 | $1.3M |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDir | May 4 | SPLAN | 59,508 | $74.90 | $4.5M |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDir | May 4 | MPLAN | 16,000 | $64.80 | $1.0M |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDir | May 4 | MPLAN | 12,000 | $60.20 | $722K |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDir | May 4 | MPLAN | 16,000 | $42.88 | $686K |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDir | May 4 | MPLAN | 10,321 | $41.08 | $424K |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDir | May 4 | MPLAN | 12,000 | $40.05 | $481K |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDir | May 4 | MPLAN | 10,968 | $38.06 | $417K |
| CYPHERPUNK TECHNOLOGIES INC. | CYPH | Joseph LoscalzoDirDERIV | Mar 13 | M | 94,050 | $0.00 | —? |
| CYPHERPUNK TECHNOLOGIES INC. | CYPH | Joseph LoscalzoDirDERIV | Mar 13 | M | 74,700 | $0.00 | —? |
| CYPHERPUNK TECHNOLOGIES INC. | CYPH | Joseph LoscalzoDir | Mar 13 | M | 94,050 | — | — |
| CYPHERPUNK TECHNOLOGIES INC. | CYPH | Joseph LoscalzoDir | Mar 13 | M | 74,700 | — | — |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDirDERIV | Mar 4 | MPLAN | 200 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDirDERIV | Mar 3 | MPLAN | 832 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDir | Mar 4 | SPLAN | 200 | $80.00 | $16K |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDir | Mar 4 | MPLAN | 200 | $38.06 | $8K |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDir | Mar 3 | SPLAN | 832 | $80.33 | $67K |
| IONIS PHARMACEUTICALS INC | IONS | Joseph LoscalzoDir | Mar 3 | MPLAN | 832 | $38.06 | $32K |
| CYPHERPUNK TECHNOLOGIES INC. | CYPH | Joseph LoscalzoDirDERIV | Dec 23 | A | 94,050 | $0.00 | —? |
| CYPHERPUNK TECHNOLOGIES INC. | CYPH | Joseph LoscalzoDirDERIV | Nov 11 | A | 74,700 | $0.00 | —? |