| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Aug 31 | J | 110 | $51.31 | $6K |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChiefDERIV | Jul 7 | JPLAN | 15,000 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Jul 7 | SPLAN | 15,000 | $85.46 | $1.3M |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Jul 7 | JPLAN | 15,000 | $0.00 | — |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Jul 7 | SPLAN | 5,536 | $83.58 | $463K |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChiefDERIV | Mar 3 | MPLAN | 48,626 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChiefDERIV | Mar 3 | MPLAN | 16,463 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Mar 3 | SPLAN | 802 | $80.76 | $65K |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Mar 3 | SPLAN | 12,687 | $79.88 | $1.0M |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Mar 3 | SPLAN | 71,600 | $79.10 | $5.7M |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Mar 3 | MPLAN | 48,626 | $60.89 | $3.0M |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Mar 3 | MPLAN | 16,463 | $32.60 | $537K |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Feb 27 | J | 261 | $48.87 | $13K |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChiefDERIV | Feb 2 | MPLAN | 48,626 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChiefDERIV | Feb 2 | MPLAN | 16,463 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Feb 2 | SPLAN | 16,463 | $83.03 | $1.4M |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Feb 2 | MPLAN | 16,463 | $32.60 | $537K |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Feb 2 | SPLAN | 48,626 | $83.03 | $4.0M |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Feb 2 | MPLAN | 48,626 | $60.89 | $3.0M |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Feb 2 | SPLAN | 20,000 | $82.60 | $1.7M |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Jan 30 | S | 5,885 | $82.95 | $488K |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Jan 29 | A | 11,421 | $0.00 | — |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChiefDERIV | Jan 15 | A | 9,675 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChiefDERIV | Jan 15 | M | 21,055 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChiefDERIV | Jan 15 | A | 25,800 | $0.00 | —? |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Jan 16 | S | 8,977 | $75.15 | $675K |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChief | Jan 15 | M | 21,055 | $0.00 | — |
| IONIS PHARMACEUTICALS INC | IONS | C. Frank BennettChiefDERIV | Jan 2 | A | 19,350 | $0.00 | —? |