348 transactions by 16 insiders, from October 13, 2025 to October 1, 2026.
People inside the company. What they do with their own shares is the reason this data exists.
| Insider | Trades | Planned | Bought | Sold |
|---|---|---|---|---|
| Bruce BoothDir | 157 | 142/157 | — | $217.7M |
| Jeremy G. ChadwickCOO | 51 | 42/51 | — | $15.6M |
| Nello MainolfiCEO | 34 | 31/34 | — | $23.7M |
| Bruce N. JacobsCFO | 23 | 10/23 | — | $10.0M |
| Pamela EspositoDir | 19 | 16/19 | — | $790K |
| Noah GoodmanChief | 17 | 15/17 | — | $2.2M |
| Elena RidloffDir | 11 | 10/11 | — | $1.3M |
| Jared GollobCMO | 9 | — | — | $917K |
| Jeffrey W. AlbersDir | 8 | 7/8 | — | $745K |
| BVF PARTNERS L P/ILDir | 5 | — | — | $173.7M |
| Brian AdamsGC | 5 | — | — | $744K |
| BAKER BROS. ADVISORS LPDir | 4 | — | $172.5M | — |
| Terence RooneyCMO | 2 | — | — | — |
| Victor SandorDir | 1 | — | — | — |
| Gorjan HrustanovicDir | 1 | — | — | — |
| John MaraganoreDir | 1 | — | — | — |
348 in total, newest filings first.
| Insider | Date | Code | Shares | Price | Value |
|---|---|---|---|---|---|
| Nello MainolfiCEODERIV | Oct 1 | MPLAN | 30,000 | $0.00 | —? |
| Nello MainolfiCEO | Oct 1 | SPLAN | 262 | $116.12 | $30K |
| Nello MainolfiCEO | Oct 1 | SPLAN | 8,230 | $115.40 | $950K |
| Nello MainolfiCEO | Oct 1 | SPLAN | 7,601 | $114.43 | $870K |
| Nello MainolfiCEO | Oct 1 | SPLAN | 4,876 | $113.24 | $552K |
| Nello MainolfiCEO | Oct 1 | SPLAN | 5,506 | $112.42 | $619K |
| Nello MainolfiCEO | Oct 1 | SPLAN | 3,525 | $111.44 | $393K |
| Nello MainolfiCEO | Oct 1 | MPLAN | 30,000 | $2.08 | $62K |
| Brian AdamsGC | Sep 4 | S | 2,137 | $117.57 | $251K |
| Brian AdamsGC | Sep 4 | S | 3,025 | $116.81 | $353K |
| Brian AdamsGC | Sep 4 | S | 1,209 | $115.55 | $140K |
| Terence RooneyCMODERIV | Jul 27 | A | 76,000 | $0.00 | —? |
| Terence RooneyCMO | Jul 27 | A | 38,000 | $0.00 | — |
| Nello MainolfiCEODERIV | Jul 7 | MPLAN | 4,441 | $0.00 | —? |
| Nello MainolfiCEODERIV | Jul 7 | MPLAN | 45,559 | $0.00 | —? |
| Nello MainolfiCEO | Jul 7 | SPLAN | 50,000 | $119.00 | $6.0M |
| Nello MainolfiCEO | Jul 7 | MPLAN | 50,000 | $2.08 | $104K |
| Nello MainolfiCEODERIV | Jul 1 | MPLAN | 80,000 | $0.00 | —? |
| Nello MainolfiCEO | Jul 1 | SPLAN | 3,336 | $116.56 | $389K |
| Nello MainolfiCEO | Jul 1 | SPLAN | 44,050 | $115.69 | $5.1M |
| Nello MainolfiCEO | Jul 1 | SPLAN | 24,105 | $114.96 | $2.8M |
| Nello MainolfiCEO | Jul 1 | SPLAN | 6,626 | $113.98 | $755K |
| Nello MainolfiCEO | Jul 1 | SPLAN | 1,883 | $112.80 | $212K |
| Nello MainolfiCEO | Jul 1 | MPLAN | 80,000 | $2.08 | $166K |
| Bruce N. JacobsCFODERIV | Jun 30 | MPLAN | 61,378 | $0.00 | —? |
| Bruce N. JacobsCFO | Jun 30 | SPLAN | 3,200 | $117.70 | $377K |
| Bruce N. JacobsCFO | Jun 30 | SPLAN | 6,153 | $116.99 | $720K |
| Bruce N. JacobsCFO | Jun 30 | SPLAN | 7,971 | $115.82 | $923K |
| Bruce N. JacobsCFO | Jun 30 | SPLAN | 51,375 | $114.77 | $5.9M |
| Bruce N. JacobsCFO | Jun 30 | SPLAN | 4,110 | $114.19 | $469K |
| Bruce N. JacobsCFO | Jun 30 | SPLAN | 1,100 | $112.79 | $124K |
| Bruce N. JacobsCFO | Jun 30 | SPLAN | 1,700 | $111.57 | $190K |
| Bruce N. JacobsCFO | Jun 30 | SPLAN | 1,500 | $110.54 | $166K |
| Bruce N. JacobsCFO | Jun 30 | MPLAN | 61,378 | $5.33 | $327K |
| Noah GoodmanChief | Jul 1 | SPLAN | 3,389 | $114.29 | $387K |
| Bruce BoothDir | Jun 29 | SPLAN | 157 | $111.20 | $17K |
| Bruce BoothDir | Jun 29 | SPLAN | 1,199 | $110.67 | $133K |
| Bruce BoothDir | Jun 29 | SPLAN | 1,239 | $109.75 | $136K |
| Bruce BoothDir | Jun 29 | SPLAN | 1,688 | $108.28 | $183K |
| Bruce BoothDir | Jun 29 | SPLAN | 907 | $111.20 | $101K |
| Bruce BoothDir | Jun 29 | SPLAN | 7,602 | $110.67 | $841K |
| Bruce BoothDir | Jun 29 | SPLAN | 7,833 | $109.75 | $860K |
| Bruce BoothDir | Jun 29 | SPLAN | 10,658 | $108.28 | $1.2M |
| Bruce BoothDir | Jun 29 | SPLAN | 3,024 | $107.76 | $326K |
| Bruce BoothDir | Jun 29 | SPLAN | 2,318 | $106.63 | $247K |
| Bruce BoothDir | Jun 29 | SPLAN | 848 | $105.78 | $90K |
| Bruce BoothDir | Jun 29 | SPLAN | 19,093 | $107.76 | $2.1M |
| Bruce BoothDir | Jun 29 | SPLAN | 14,613 | $106.63 | $1.6M |
| Bruce BoothDir | Jun 29 | SPLAN | 5,471 | $105.78 | $579K |
| Bruce BoothDir | Jun 26 | SPLAN | 1,729 | $118.66 | $205K |
| Bruce BoothDir | Jun 26 | SPLAN | 3,069 | $117.85 | $362K |
| Bruce BoothDir | Jun 26 | SPLAN | 1,701 | $117.09 | $199K |
| Bruce BoothDir | Jun 26 | SPLAN | 952 | $115.69 | $110K |
| Bruce BoothDir | Jun 26 | SPLAN | 3,896 | $114.94 | $448K |
| Bruce BoothDir | Jun 26 | SPLAN | 2,083 | $113.97 | $237K |
| Bruce BoothDir | Jun 26 | SPLAN | 78 | $112.49 | $9K |
| Bruce BoothDir | Jun 26 | SPLAN | 1,442 | $111.51 | $161K |
| Bruce BoothDir | Jun 26 | SPLAN | 1,579 | $110.49 | $174K |
| Bruce BoothDir | Jun 26 | SPLAN | 4,562 | $109.79 | $501K |
| Bruce BoothDir | Jun 26 | SPLAN | 32,402 | $108.14 | $3.5M |
| Bruce BoothDir | Jun 26 | SPLAN | 3,958 | $107.57 | $426K |
| Bruce BoothDir | Jun 26 | SPLAN | 12,390 | $118.66 | $1.5M |
| Bruce BoothDir | Jun 26 | SPLAN | 22,046 | $117.85 | $2.6M |
| Bruce BoothDir | Jun 26 | SPLAN | 12,181 | $117.09 | $1.4M |
| Bruce BoothDir | Jun 26 | SPLAN | 6,821 | $115.69 | $789K |
| Bruce BoothDir | Jun 26 | SPLAN | 27,951 | $114.94 | $3.2M |
| Bruce BoothDir | Jun 26 | SPLAN | 14,913 | $113.97 | $1.7M |
| Bruce BoothDir | Jun 26 | SPLAN | 555 | $112.49 | $62K |
| Bruce BoothDir | Jun 26 | SPLAN | 10,366 | $111.51 | $1.2M |
| Bruce BoothDir | Jun 26 | SPLAN | 11,277 | $110.49 | $1.2M |
| Bruce BoothDir | Jun 26 | SPLAN | 32,624 | $109.79 | $3.6M |
| Bruce BoothDir | Jun 26 | SPLAN | 231,007 | $108.14 | $25.0M |
| Bruce BoothDir | Jun 26 | SPLAN | 28,296 | $107.57 | $3.0M |
| BVF PARTNERS L P/ILDirJOINT | Jun 26 | S | 51,858 | $106.50 | $5.5M |
| BVF PARTNERS L P/ILDirJOINT | Jun 26 | S | 113,289 | $106.50 | $12.1M |
| BVF PARTNERS L P/ILDirJOINT | Jun 26 | S | 627,597 | $106.50 | $66.8M |
| BVF PARTNERS L P/ILDirJOINT | Jun 26 | S | 837,914 | $106.50 | $89.2M |
| Elena RidloffDirDERIV | Jun 24 | A | 6,068 | $0.00 | —? |
| John MaraganoreDirDERIV | Jun 24 | A | 6,068 | $0.00 | —? |
| Victor SandorDirDERIV | Jun 24 | A | 6,068 | $0.00 | —? |
| Gorjan HrustanovicDirDERIV | Jun 24 | A | 6,068 | $0.00 | —? |
| Noah GoodmanChiefDERIV | Jun 25 | MPLAN | 5,000 | $0.00 | —? |
| Noah GoodmanChief | Jun 25 | SPLAN | 2,500 | $119.00 | $298K |
| Noah GoodmanChief | Jun 25 | SPLAN | 2,500 | $109.00 | $273K |
| Noah GoodmanChief | Jun 25 | MPLAN | 5,000 | $21.05 | $105K |
| Pamela EspositoDirDERIV | Jun 24 | A | 6,068 | $0.00 | —? |
| Bruce BoothDir | Jun 25 | SPLAN | 46 | $129.61 | $6K |
| Bruce BoothDir | Jun 25 | SPLAN | 305 | $128.69 | $39K |
| Bruce BoothDir | Jun 25 | SPLAN | 3,507 | $127.37 | $447K |
| Bruce BoothDir | Jun 25 | SPLAN | 223 | $126.71 | $28K |
| Bruce BoothDir | Jun 25 | SPLAN | 522 | $125.82 | $66K |
| Bruce BoothDir | Jun 25 | SPLAN | 1,639 | $124.61 | $204K |
| Bruce BoothDir | Jun 25 | SPLAN | 1,517 | $123.62 | $188K |
| Bruce BoothDir | Jun 25 | SPLAN | 698 | $122.67 | $86K |
| Bruce BoothDir | Jun 25 | SPLAN | 5,689 | $121.38 | $691K |
| Bruce BoothDir | Jun 25 | SPLAN | 15,660 | $120.66 | $1.9M |
| Bruce BoothDir | Jun 25 | SPLAN | 5,144 | $119.71 | $616K |
| Bruce BoothDir | Jun 25 | SPLAN | 337 | $129.61 | $44K |
| Bruce BoothDir | Jun 25 | SPLAN | 2,197 | $128.69 | $283K |
| Bruce BoothDir | Jun 25 | SPLAN | 25,075 | $127.37 | $3.2M |
| Bruce BoothDir | Jun 25 | SPLAN | 1,609 | $126.71 | $204K |
| Bruce BoothDir | Jun 25 | SPLAN | 3,716 | $125.82 | $468K |
| Bruce BoothDir | Jun 25 | SPLAN | 11,711 | $124.61 | $1.5M |
| Bruce BoothDir | Jun 25 | SPLAN | 10,860 | $123.62 | $1.3M |
| Bruce BoothDir | Jun 25 | SPLAN | 4,977 | $122.67 | $611K |
| Bruce BoothDir | Jun 25 | SPLAN | 40,774 | $121.38 | $4.9M |
| Bruce BoothDir | Jun 25 | SPLAN | 112,299 | $120.66 | $13.5M |
| Bruce BoothDir | Jun 25 | SPLAN | 37,179 | $119.71 | $4.5M |
| Bruce BoothDir | Jun 25 | SPLAN | 2,646 | $118.60 | $314K |
| Bruce BoothDir | Jun 25 | SPLAN | 3,359 | $117.50 | $395K |
| Bruce BoothDir | Jun 25 | SPLAN | 11,375 | $116.53 | $1.3M |
| Bruce BoothDir | Jun 25 | SPLAN | 8,389 | $115.57 | $970K |
| Bruce BoothDir | Jun 25 | SPLAN | 1,289 | $114.65 | $148K |
| Bruce BoothDir | Jun 25 | SPLAN | 1,437 | $113.70 | $163K |
| Bruce BoothDir | Jun 25 | SPLAN | 100 | $111.89 | $11K |
| Bruce BoothDir | Jun 25 | SPLAN | 86 | $110.79 | $10K |
| Bruce BoothDir | Jun 25 | SPLAN | 265 | $110.30 | $29K |
| Bruce BoothDir | Jun 25 | SPLAN | 2,011 | $108.83 | $219K |
| Bruce BoothDir | Jun 25 | SPLAN | 23 | $108.02 | $2K |
| Bruce BoothDir | Jun 25 | SPLAN | 1,399 | $107.30 | $150K |
| Bruce BoothDir | Jun 25 | SPLAN | 19,089 | $118.60 | $2.3M |
| Bruce BoothDir | Jun 25 | SPLAN | 24,268 | $117.50 | $2.9M |
| Bruce BoothDir | Jun 25 | SPLAN | 81,500 | $116.53 | $9.5M |
| Bruce BoothDir | Jun 25 | SPLAN | 58,205 | $115.57 | $6.7M |
| Bruce BoothDir | Jun 25 | SPLAN | 9,229 | $114.65 | $1.1M |
| Bruce BoothDir | Jun 25 | SPLAN | 10,215 | $113.70 | $1.2M |
| Bruce BoothDir | Jun 25 | SPLAN | 719 | $111.89 | $80K |
| Bruce BoothDir | Jun 25 | SPLAN | 614 | $110.79 | $68K |
| Bruce BoothDir | Jun 25 | SPLAN | 1,915 | $110.30 | $211K |
| Bruce BoothDir | Jun 25 | SPLAN | 14,351 | $108.83 | $1.6M |
| Bruce BoothDir | Jun 25 | SPLAN | 159 | $108.02 | $17K |
| Bruce BoothDir | Jun 25 | SPLAN | 9,994 | $107.30 | $1.1M |
| Bruce BoothDir | Jun 24 | SPLAN | 2,029 | $101.14 | $205K |
| Bruce BoothDir | Jun 24 | SPLAN | 14,490 | $101.14 | $1.5M |
| Bruce BoothDir | Jun 24 | SPLAN | 14,513 | $100.42 | $1.5M |
| Bruce BoothDir | Jun 24 | SPLAN | 103,688 | $100.42 | $10.4M |
| Bruce BoothDir | Jun 23 | SPLAN | 173 | $99.98 | $17K |
| Bruce BoothDir | Jun 23 | SPLAN | 1,235 | $99.98 | $123K |
| Bruce BoothDirDERIV | Jun 24 | A | 6,068 | $0.00 | —? |
| BVF PARTNERS L P/ILDirDERIVJOINT | Jun 24 | A | 6,068 | $0.00 | —? |
| Jeffrey W. AlbersDirDERIV | Jun 24 | A | 6,068 | $0.00 | —? |
| BAKER BROS. ADVISORS LPDirDERIVJOINT | Jun 24 | A | 6,068 | $0.00 | —? |
| BAKER BROS. ADVISORS LPDirDERIVJOINT | Jun 24 | A | 6,068 | $0.00 | —? |
| Noah GoodmanChiefDERIV | Jun 22 | MPLAN | 2,500 | $0.00 | —? |
| Noah GoodmanChief | Jun 22 | SPLAN | 2,500 | $99.00 | $248K |
| Noah GoodmanChief | Jun 22 | MPLAN | 2,500 | $21.05 | $53K |
| Bruce BoothDir | Jun 22 | SPLAN | 1,341 | $104.38 | $140K |
| Bruce BoothDir | Jun 22 | SPLAN | 2,560 | $103.42 | $265K |
| Bruce BoothDir | Jun 22 | SPLAN | 9,584 | $104.38 | $1.0M |
| Bruce BoothDir | Jun 22 | SPLAN | 18,313 | $103.42 | $1.9M |
| Bruce BoothDirDERIV | Jun 17 | MPLAN | 11,741 | $0.00 | —? |
| Bruce BoothDir | Jun 22 | SPLAN | 1,253 | $102.48 | $128K |
| Bruce BoothDir | Jun 22 | SPLAN | 918 | $101.61 | $93K |
| Bruce BoothDir | Jun 22 | SPLAN | 7,879 | $100.17 | $789K |
| Bruce BoothDir | Jun 22 | SPLAN | 7,319 | $99.57 | $729K |
| Bruce BoothDir | Jun 22 | SPLAN | 3,603 | $98.58 | $355K |
| Bruce BoothDir | Jun 22 | SPLAN | 2,247 | $97.68 | $219K |
| Bruce BoothDir | Jun 22 | SPLAN | 2,919 | $96.24 | $281K |
| Bruce BoothDir | Jun 22 | SPLAN | 1,648 | $95.12 | $157K |
| Bruce BoothDir | Jun 22 | SPLAN | 286 | $94.48 | $27K |
| Bruce BoothDir | Jun 22 | SPLAN | 2,179 | $92.14 | $201K |
| Bruce BoothDir | Jun 22 | SPLAN | 8,990 | $102.48 | $921K |
| Bruce BoothDir | Jun 22 | SPLAN | 6,597 | $101.61 | $670K |
| Bruce BoothDir | Jun 22 | SPLAN | 56,348 | $100.17 | $5.6M |
| Bruce BoothDir | Jun 22 | SPLAN | 52,442 | $99.57 | $5.2M |
| Bruce BoothDir | Jun 22 | SPLAN | 25,976 | $98.58 | $2.6M |
| Bruce BoothDir | Jun 22 | SPLAN | 16,084 | $97.68 | $1.6M |
| Bruce BoothDir | Jun 22 | SPLAN | 20,903 | $96.24 | $2.0M |
| Bruce BoothDir | Jun 22 | SPLAN | 11,783 | $95.12 | $1.1M |
| Bruce BoothDir | Jun 22 | SPLAN | 2,035 | $94.48 | $192K |
| Bruce BoothDir | Jun 22 | SPLAN | 14,921 | $92.14 | $1.4M |
| Bruce BoothDir | Jun 18 | SPLAN | 793 | $92.16 | $73K |
| Bruce BoothDir | Jun 18 | SPLAN | 4,526 | $91.85 | $416K |
| Bruce BoothDir | Jun 18 | SPLAN | 8,809 | $90.48 | $797K |
| Bruce BoothDir | Jun 18 | SPLAN | 5,672 | $92.16 | $523K |
| Bruce BoothDir | Jun 18 | SPLAN | 32,359 | $91.85 | $3.0M |
| Bruce BoothDir | Jun 18 | SPLAN | 62,897 | $90.48 | $5.7M |
| Bruce BoothDir | Jun 17 | SPLAN | 12,902 | $90.38 | $1.2M |
| Bruce BoothDir | Jun 17 | SPLAN | 92,169 | $90.38 | $8.3M |
| Bruce BoothDir | Jun 17 | SPLAN | 11,741 | $89.98 | $1.1M |
| Bruce BoothDir | Jun 17 | MPLAN | 11,741 | $20.00 | $235K |
| Bruce N. JacobsCFODERIV | Jun 2 | M | 12,653 | $0.00 | —? |
| Bruce N. JacobsCFO | Jun 2 | M | 12,653 | $2.08 | $26K |
| Jeremy G. ChadwickCOO | May 27 | SPLAN | 600 | $82.08 | $49K |
| Jeremy G. ChadwickCOO | May 27 | SPLAN | 3,679 | $81.50 | $300K |
| Jeremy G. ChadwickCOO | May 26 | SPLAN | 551 | $80.71 | $44K |
| Jeremy G. ChadwickCOO | May 26 | SPLAN | 4,500 | $80.02 | $360K |
| Jeremy G. ChadwickCOO | May 26 | SPLAN | 3,800 | $79.39 | $302K |
| Jeremy G. ChadwickCOO | May 26 | SPLAN | 324 | $79.17 | $26K |
| Jeremy G. ChadwickCOO | May 26 | SPLAN | 3,730 | $78.36 | $292K |
| Bruce N. JacobsCFODERIV | May 18 | M | 15,000 | $0.00 | —? |
| Bruce N. JacobsCFO | May 18 | M | 15,000 | $2.08 | $31K |
| Pamela EspositoDirDERIV | May 19 | M | 1,000 | $0.00 | —? |
| Pamela EspositoDir | May 19 | M | 1,000 | $31.20 | $31K |
| Elena RidloffDirDERIV | May 11 | MPLAN | 3,000 | $0.00 | —? |
| Elena RidloffDir | May 11 | SPLAN | 3,000 | $87.00 | $261K |
| Elena RidloffDir | May 11 | MPLAN | 3,000 | $31.20 | $94K |
| Nello MainolfiCEODERIV | Apr 29 | MPLAN | 30,000 | $0.00 | —? |
| Nello MainolfiCEO | Apr 29 | SPLAN | 936 | $82.45 | $77K |
| Nello MainolfiCEO | Apr 29 | SPLAN | 12,059 | $81.70 | $985K |