| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Nov 6 | MPLANOption exercise | 18,300 | $0.00 | —? | 0derivatives |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Nov 5 | MPLANOption exercise | 801 | $0.00 | —? | 18,300derivatives |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Nov 6 | MPLANOption exercise | 14,738 | $0.00 | —? | 0derivatives |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Nov 5 | MPLANOption exercise | 800 | $0.00 | —? | 14,738derivatives |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Nov 6 | SPLAN | 18,300 | $75.42 | $1.4M | 59,657 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Nov 6 | MPLANOption exercise | 18,300 | $60.89 | $1.1M | 77,957 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Nov 6 | SPLAN | 14,738 | $76.10 | $1.1M | 59,657 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Nov 6 | MPLANOption exercise | 14,738 | $56.78 | $837K | 74,395 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Nov 5 | SPLAN | 801 | $75.01 | $60K | 59,657 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Nov 5 | MPLANOption exercise | 801 | $60.89 | $49K | 60,458 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Nov 5 | SPLAN | 800 | $75.01 | $60K | 59,657 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Nov 5 | MPLANOption exercise | 800 | $56.78 | $45K | 60,457 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Nov 3 | MPLANOption exercise | 905 | $0.00 | —? | 18,971derivatives |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Oct 31 | MPLANOption exercise | 34,585 | $0.00 | —? | 19,876derivatives |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Nov 3 | MPLANOption exercise | 775 | $0.00 | —? | 15,668derivatives |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Oct 31 | MPLANOption exercise | 34,664 | $0.00 | —? | 16,443derivatives |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Nov 3 | SPLAN | 905 | $75.05 | $68K | 59,657 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Nov 3 | MPLANOption exercise | 905 | $60.89 | $55K | 60,562 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Nov 3 | SPLAN | 775 | $75.05 | $58K | 59,657 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Nov 3 | MPLANOption exercise | 775 | $56.78 | $44K | 60,432 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Oct 31 | SPLAN | 20,000 | $75.11 | $1.5M | 59,657 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Oct 31 | SPLAN | 34,664 | $75.11 | $2.6M | 79,657 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Oct 31 | MPLANOption exercise | 34,664 | $56.78 | $2.0M | 114,321 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Oct 31 | SPLAN | 34,585 | $75.11 | $2.6M | 79,657 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Oct 31 | MPLANOption exercise | 34,585 | $60.89 | $2.1M | 114,242 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Sep 30 | MPLANOption exercise | 57,900 | $0.00 | —? | 0derivatives |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Sep 30 | SPLAN | 57,900 | $65.24 | $3.8M | 79,657 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Sep 30 | MPLANOption exercise | 57,900 | $53.77 | $3.1M | 137,557 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Sep 2 | SPLAN | 10,000 | $50.37 | $504K | 79,657 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Aug 29 | JOther | 165 | $27.71 | $5K | 89,657 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Aug 5 | SPLAN | 10,000 | $42.86 | $429K | 89,492 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Feb 28 | JOther | 415 | $28.21 | $12K | 99,492 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Jan 31 | S | 1,406 | $32.40 | $46K | 99,077 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Jan 30 | AAward | 3,820 | $0.00 | — | 100,483 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Jan 15 | MOption exercise | 18,901 | $0.00 | —? | 60,724derivatives |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Jan 15 | AAward | 33,000 | $0.00 | —? | 79,625derivatives |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Jan 15 | AAward | 22,000 | $0.00 | —? | 64,801derivatives |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Jan 16 | S | 7,072 | $32.86 | $232K | 96,663 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChief | Jan 15 | MOption exercise | 18,901 | $0.00 | — | 103,735 |
| IONIS PHARMACEUTICALS INC | IONS | Richard S. GearyChiefDERIV | Jan 2 | AAward | 22,000 | $0.00 | —? | 22,000derivatives |